Nature Communications (Feb 2017)
A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
Abstract
Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product.