Granulocyte colony‐stimulating factor associated arteritis in a patient with castration‐resistant prostate cancer

Abstract

Introduction Granulocyte colony‐stimulating factor‐associated arteritis is a rare adverse event of granulocyte colony‐stimulating factor, with an incidence of 0.47% among all patients who receive granulocyte colony‐stimulating factor. We herein present a case of granulocyte colony‐stimulating factor‐associated arteritis. Case presentation A 72‐year‐old man with castration‐resistant prostate cancer and multiple bone metastases was treated with docetaxel and pegfilgrastim. He developed a high fever on day 12 without other symptoms. His white blood cell count and C‐reactive protein levels were high. Antibiotic therapy was ineffective, and contrast‐enhanced computed tomography showed thickened subclavian and brachiocephalic artery walls. He was diagnosed with granulocyte colony‐stimulating factor‐associated arteritis. Conclusion When patients receiving chemotherapy with granulocyte colony‐stimulating factor develop an unexplained fever, granulocyte colony‐stimulating factor associated arteritis should be considered.

Keywords

• arteritis
• castration‐resistant prostate cancer
• docetaxel
• granulocyte colony‐stimulating factor
• prednisolone