Nature Communications (Dec 2022)
A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance
- Jing-Jing Yan,
- Xiao-Jing Ding,
- Ting He,
- Ai-Xiao Chen,
- Wen Zhang,
- Zi-Xian Yu,
- Xin-Yu Cheng,
- Chuan-Yao Wei,
- Qiao-Dan Hu,
- Xiao-Yao Liu,
- Yan-Li Zhang,
- Mengge He,
- Zhi-Yong Xie,
- Xi Zha,
- Chun Xu,
- Peng Cao,
- Haohong Li,
- Xiao-Hong Xu
Affiliations
- Jing-Jing Yan
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Xiao-Jing Ding
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Ting He
- Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
- Ai-Xiao Chen
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Wen Zhang
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Zi-Xian Yu
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Xin-Yu Cheng
- National Institute of Biological Sciences
- Chuan-Yao Wei
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Qiao-Dan Hu
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Xiao-Yao Liu
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Yan-Li Zhang
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Mengge He
- Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
- Zhi-Yong Xie
- National Institute of Biological Sciences
- Xi Zha
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Chun Xu
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- Peng Cao
- National Institute of Biological Sciences
- Haohong Li
- The MOE Frontier Research Center of Brain & Brain machine Integration, Zhejiang University School of Brain Science and Brain Medicine
- Xiao-Hong Xu
- Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-35211-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Anxiety is thought to be evolutionarily rooted in predator defense. Yan et al. show that GABAergic neurons in the anterior hypothalamic nucleus (AHN), a node in the predator defense network, play an essential role in anxiety-like behaviors.
