Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

Abstract

Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented.

Keywords

• dipeptide isosteres
• monofluoroalkene-based amide bonds
• monofluoroalkenes
• peptides
• synthesis