Avicenna Journal of Phytomedicine (May 2013)

Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves

  • Badrul Alam,
  • Fahima Akter,
  • Nahida Parvin,
  • Rashna Sharmin Pia,
  • Sharmin Akter,
  • Jesmin Chowdhury,
  • Kazi Sifath-E-Jahan,
  • Ekramul Haque Haque

Journal volume & issue
Vol. 3, no. 2
pp. 112 – 125

Abstract

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Objective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO-) as well as inhibition of total ROS generation, and assessment of reducing power were used to evaluate antioxidant potential of MPBL. Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (p

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