Frontiers in Microbiology (Jul 2020)

Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro

  • Nicola Clementi,
  • Nicola Clementi,
  • Elena Criscuolo,
  • Roberta Antonia Diotti,
  • Roberto Ferrarese,
  • Matteo Castelli,
  • Lorenzo Dagna,
  • Roberto Burioni,
  • Massimo Clementi,
  • Massimo Clementi,
  • Nicasio Mancini,
  • Nicasio Mancini

DOI
https://doi.org/10.3389/fmicb.2020.01704
Journal volume & issue
Vol. 11

Abstract

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While the SARS-CoV-2 pandemic is heavily hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. In this study, we evidence that the anti-SARS-CoV2 activity of a clinically achievable hydroxychloroquine concentration is maximized only when administered before and after the infection of Vero E6 and Caco-2 cells. This suggests that only a combined prophylactic and therapeutic use of hydroxychloroquine may be effective in limiting viral replication in patients.

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