Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Jiyuan Zhang; Xin Guan; Kunal Shah; Jiusheng Yan

doi:10.1038/s41467-021-24735-z

Nature Communications (Aug 2021)

Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Jiyuan Zhang,
Xin Guan,
Kunal Shah,
Jiusheng Yan

Affiliations

Jiyuan Zhang: Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center
Xin Guan: Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center
Kunal Shah: Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center
Jiusheng Yan: Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-021-24735-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca2+ mobilizing second messenger which uniquely triggers Ca2+ release from acidic endolysosomal organelles. Here the authors identify Lsm12 as an NAADP receptor essential for NAADP-evoked Ca2+ release from lysosomes via NAADP binding on its Lsm domain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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