A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Kaivalya Walavalkar; Bharath Saravanan; Anurag Kumar Singh; Ranveer Singh Jayani; Ashwin Nair; Umer Farooq; Zubairul Islam; Deepanshu Soota; Rajat Mann; Padubidri V. Shivaprasad; Matthew L. Freedman; Radhakrishnan Sabarinathan; Christopher A. Haiman; Dimple Notani

doi:10.1038/s41467-020-17325-y

Nature Communications (Jul 2020)

A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Kaivalya Walavalkar,
Bharath Saravanan,
Anurag Kumar Singh,
Ranveer Singh Jayani,
Ashwin Nair,
Umer Farooq,
Zubairul Islam,
Deepanshu Soota,
Rajat Mann,
Padubidri V. Shivaprasad,
Matthew L. Freedman,
Radhakrishnan Sabarinathan,
Christopher A. Haiman,
Dimple Notani

Affiliations

Kaivalya Walavalkar: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Bharath Saravanan: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Anurag Kumar Singh: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Ranveer Singh Jayani: Howard Hughes Medical Institute, Department of Medicine, University of California San Diego
Ashwin Nair: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Umer Farooq: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Zubairul Islam: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Deepanshu Soota: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Rajat Mann: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Padubidri V. Shivaprasad: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Matthew L. Freedman: Department of Medical Oncology, Dana-Farber Cancer Institute
Radhakrishnan Sabarinathan: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research
Christopher A. Haiman: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Dimple Notani: Genetics and Development, National Centre for Biological Sciences, Tata Institute of Fundamental Research

DOI: https://doi.org/10.1038/s41467-020-17325-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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