Integration of genome-wide mRNA and miRNA expression, and DNA methylation data of three cell lines exposed to ten carbon nanomaterials
Giovanni Scala,
Veer Marwah,
Pia Kinaret,
Jukka Sund,
Vittorio Fortino,
Dario Greco
Affiliations
Giovanni Scala
Faculty of Medicine and Life Sciences, University of Tampere, Finland; Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland; Institute of Biotechnology, University of Helsinki, Finland
Veer Marwah
Faculty of Medicine and Life Sciences, University of Tampere, Finland; Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland
Pia Kinaret
Faculty of Medicine and Life Sciences, University of Tampere, Finland; Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland; Institute of Biotechnology, University of Helsinki, Finland
Jukka Sund
Faculty of Medicine and Life Sciences, University of Tampere, Finland
Vittorio Fortino
Faculty of Medicine and Life Sciences, University of Tampere, Finland; Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland; Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Finland
Dario Greco
Faculty of Medicine and Life Sciences, University of Tampere, Finland; Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland; Institute of Biotechnology, University of Helsinki, Finland; Corresponding author at: Faculty of Medicine and Life Sciences, University of Tampere, Finland.
We present data derived from an exposure experiment in which three cell-lines representative of cell types of the respiratory tissue (epithelial type-I A549, epithelial type-II BEAS-2B, and macrophage THP-1) have been exposed to ten different carbon-based nanomaterials for 48 h.In particular, we provide: genome-wide mRNA and miRNA expression, and DNA methylation; gene tables, containing information on the aberrations induced in these three genomic data layers at the gene level; mechanism of action (MOA) maps representing the comparative functional alteration induced in each cell line and each exposure.
