Reports
(Oct 2021)
NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors
Shivanand Pudakalakatti,
Alessandra Audia,
Anirudh Mukhopadhyay,
José S. Enriquez,
Dontrey Bourgeois,
Nabihah Tayob,
Niki M. Zacharias,
Steven W. Millward,
Daniel Carson,
Mary C. Farach-Carson,
Frederick F. Lang,
Amy B. Heimberger,
Krishna P. Bhat,
Pratip K. Bhattacharya
Affiliations
Shivanand Pudakalakatti
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Alessandra Audia
Department of Translational Molecular Pathology, The University of Texas MD Anderson Center Center, Houston, TX 77030, USA
Anirudh Mukhopadhyay
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
José S. Enriquez
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Dontrey Bourgeois
Department of Statistics, Rice University, Houston, TX 77005, USA
Nabihah Tayob
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Niki M. Zacharias
MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA
Steven W. Millward
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Daniel Carson
Department of BioSciences, Rice University, Houston, TX 77005, USA
Mary C. Farach-Carson
MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA
Frederick F. Lang
MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA
Amy B. Heimberger
MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA
Krishna P. Bhat
Department of Translational Molecular Pathology, The University of Texas MD Anderson Center Center, Houston, TX 77030, USA
Pratip K. Bhattacharya
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
DOI
https://doi.org/10.3390/reports4040032
Journal volume & issue
Vol. 4,
no. 4
Abstract
Read online
“Tumor-educated platelets” have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.
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