ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration

Jun Zhou; Bruce A. Edgar; Michael Boutros

doi:10.1038/ncomms14289

Nature Communications (Mar 2017)

ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration

Jun Zhou,
Bruce A. Edgar,
Michael Boutros

Affiliations

Jun Zhou: Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, German Cancer Research Center (DKFZ), Medical Faculty Mannheim
Bruce A. Edgar: German Cancer Research Center (DKFZ)-Center for Molecular Biology Heidelberg (ZMBH) Alliance
Michael Boutros: Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, German Cancer Research Center (DKFZ), Medical Faculty Mannheim

DOI: https://doi.org/10.1038/ncomms14289
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Stress response JNK signalling is important for cell death-induced regeneration. Here the authors show in adultDrosophilaenterocytes that ATF3 regulates the expression of Raw, a JNK antagonist, to control intestinal regeneration and barrier function in response to infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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