Stimuli may have little impact on the deficit of visual working memory accuracy in first-episode schizophrenia

Abstract

Shenglin She,1,* Bei Zhang,1,* Lin Mi,1 Haijing Li,1 Qijie Kuang,1 Taiyong Bi,2 Yingjun Zheng1 1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), National Clinical Research Center on Mental Disorders (Changsha), Guangzhou 510370, China; 2School of Management, Zunyi Medical University, Guizhou 563000, China *These authors contributed equally to this work Purpose: Working memory (WM) deficits have been observed in people with schizophrenia (SZ) and are considered a core cognitive dysfunction in these patients. However, little is known about how stimuli and memory load influence visual WM deficits. Patients and methods: In the present study, we adopted a match-to-sample task to examine the visual WM in 18 first-episode patients with SZ and 18 healthy controls (HCs). Faces and houses were used as the stimuli, and there were two levels of memory load – one item and two items; the average accuracy (ACC) and reaction time were calculated for each condition. The Positive and Negative Syndrome Scale and the Personal and Social Performance scale were used to assess the psychiatric symptoms and social function, respectively. Results: The results showed equivalent levels of WM deficit when using face and house stimuli. Moreover, the WM deficits were not related to the duration of illness, medication, or SZ symptoms. Conclusion: These results demonstrate that stimuli may have little impact on ACC in WM tasks in people with SZ. In addition, the memory load may have little impact on WM ACC when the load is relatively low. Keywords: visual working memory, first-episode schizophrenia, face perception, match-to-sample, memory load, working memory deficit

Keywords

• Visual working memory
• First-episode schizophrenia
• Face perception
• Match-to-sample
• Memory load