Drug-Resistant Breast Cancer: Dwelling the Hippo Pathway to Manage the Treatment

Abstract

Simran Kaur,1 Mohammad Zeeshan Najm,1 Mohammad Aasif Khan,2 Naseem Akhter,3 Vyas M Shingatgeri,1 Mudra Sikenis,1 Sadaf,4 Abdulaziz A Aloliqi5 1School of Bioscience, Apeejay Stya University, Gurugram, Haryana, India; 2Department of Biosciences, Jamia Millia Islamia University, New Delhi, India; 3Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al Baha University, Al Baha, Saudi Arabia; 4QuickisCool, Aitele Research LLP, Sitamarhi, Bihar, India; 5Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaCorrespondence: Sadaf; Abdulaziz A Aloliqi Email [email protected]; [email protected]: Breast cancer can be categorized as a commonly occurring cancer among women with a high mortality rate. Due to the repetitive treatment cycles, it has been noted that the patients develop resistance towards the chemotherapeutic drugs and remain unresponsive towards them. Therefore, many researchers are studying various signaling pathways involved in drug resistance for cancer treatment to overcome the obstacle. Hippo signaling is a widely studied pathway involved in tumor progression and controlling cell proliferation. Hence, understanding the aspects of the gene involved Hippo pathway would provide an insight into the mechanism behind the resistance and result in the development of new treatments. Here, we review the Hippo signaling pathway in humans and how the expression of different components leads to the regulation of resistance against some of the common chemo-drugs used in breast cancer treatment. The article will also discuss the chemotherapeutics that became ineffective due to the resistance and the mechanism following the process.Keywords: drug resistance, breast cancer, chemo drugs, Hippo signaling, YAP, LATS, TAZ

Keywords

• drug resistance
• breast cancer
• chemo drugs
• hippo signaling
• yap
• lats
• taz