Detection of Severe Murine Typhus by Nanopore Targeted Sequencing, China

Abstract

We report a case of murine typhus in China caused by Rickettsia typhi and diagnosed by nanopore targeted sequencing of a bronchoalveolar lavage fluid sample. This case highlights that nanopore targeted sequencing can effectively detect clinically unexplained infections and be especially useful for detecting infections in patients without typical signs and symptoms.

Keywords

• Murine typhus
• Rickettsia typhi
• bacteria
• rickettsia
• vector-borne infections
• zoonoses