An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

Jia-Bin Wang; Ping Li; Xiao-Long Liu; Qiao-Ling Zheng; Yu-Bin Ma; Ya-Jun Zhao; Jian-Wei Xie; Jian-Xian Lin; Jun Lu; Qi-Yue Chen; Long-Long Cao; Mi Lin; Li-Chao Liu; Ning-Zi Lian; Ying-Hong Yang; Chang-Ming Huang; Chao-Hui Zheng

doi:10.1038/s41467-020-20260-7

Nature Communications (Dec 2020)

An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

Jia-Bin Wang,
Ping Li,
Xiao-Long Liu,
Qiao-Ling Zheng,
Yu-Bin Ma,
Ya-Jun Zhao,
Jian-Wei Xie,
Jian-Xian Lin,
Jun Lu,
Qi-Yue Chen,
Long-Long Cao,
Mi Lin,
Li-Chao Liu,
Ning-Zi Lian,
Ying-Hong Yang,
Chang-Ming Huang,
Chao-Hui Zheng

Affiliations

Jia-Bin Wang: Department of Gastric Surgery, Fujian Medical University Union Hospital
Ping Li: Department of Gastric Surgery, Fujian Medical University Union Hospital
Xiao-Long Liu: The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province
Qiao-Ling Zheng: Department of Pathology, Fujian Medical University Union Hospital
Yu-Bin Ma: Department of Gastrointestinal Surgery, The Affiliated Hospital of Qinghai University
Ya-Jun Zhao: Division of Life Sciences and Medicine, Department of Gastrointestinal Surgery, The First Affiliated Hospital of USTC, University of Science and Technology of China
Jian-Wei Xie: Department of Gastric Surgery, Fujian Medical University Union Hospital
Jian-Xian Lin: Department of Gastric Surgery, Fujian Medical University Union Hospital
Jun Lu: Department of Gastric Surgery, Fujian Medical University Union Hospital
Qi-Yue Chen: Department of Gastric Surgery, Fujian Medical University Union Hospital
Long-Long Cao: Department of Gastric Surgery, Fujian Medical University Union Hospital
Mi Lin: Department of Gastric Surgery, Fujian Medical University Union Hospital
Li-Chao Liu: Department of Gastric Surgery, Fujian Medical University Union Hospital
Ning-Zi Lian: Department of Gastric Surgery, Fujian Medical University Union Hospital
Ying-Hong Yang: Department of Pathology, Fujian Medical University Union Hospital
Chang-Ming Huang: Department of Gastric Surgery, Fujian Medical University Union Hospital
Chao-Hui Zheng: Department of Gastric Surgery, Fujian Medical University Union Hospital

DOI: https://doi.org/10.1038/s41467-020-20260-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Expression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of candidates for adjuvant chemotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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