Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids

• Jianqi Feng,
• Lian Li,
• Zhihong Tan,
• Shanshan Zhao,
• Xin Zhang,
• Jinhong Wang,
• Yaping Ye,
• Ying Lin,
• Zhili Rong

Affiliations

Jianqi Feng

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China

Lian Li

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China

Zhihong Tan

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China

Shanshan Zhao

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China

Xin Zhang

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China

Jinhong Wang

Department of Respiration, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China

Yaping Ye

Department of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong 510515, China

Ying Lin

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China; Experimental Education/Administration Center, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Corresponding author. Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China.

Zhili Rong

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China; Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510091, China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, Guangdong 510005, China; Experimental Education/Administration Center, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Corresponding author. Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, Guangdong 510515, China.