Iridium-Catalysed Transfer Hydrogenation of 1,8-Naphthyridine with Indoline: Access to Functionalized N-Heteroarenes
Changjian Zhou,
Jiahao Zhang,
Yuqing Fu,
Chunlian Chen,
He Zhao
Affiliations
Changjian Zhou
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China
Jiahao Zhang
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China
Yuqing Fu
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China
Chunlian Chen
Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510640, China
He Zhao
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China
An iridium-catalysed hydrogen transfer strategy, enabling straightforward access to tetrahydro pyridine derivatives from aryl-1,8-naphthyridines and indolines, was developed. This method proceeds with unprecedented synthetic effectiveness including high step-economic fashion together with the advantages of having no by-product and no need for external high-pressure H2 gas, offering an important basis for the transformation of 1,8-naphthyridines and indolines into functionalized products.
