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Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review

Journal of Pharmacopuncture. 2019;22(4):204-209 DOI 10.3831/KPI.2019.22.028


Journal Homepage

Journal Title: Journal of Pharmacopuncture

ISSN: 2093-6966 (Print); 2234-6856 (Online)

Publisher: Korean Pharmacopuncture Institute

LCC Subject Category: Medicine: Other systems of medicine: Miscellaneous systems and treatments | Medicine: Therapeutics. Pharmacology

Country of publisher: Korea, Republic of

Language of fulltext: English, Korean

Full-text formats available: PDF, HTML, XML



Zahra Bostani Khalesi (Social Determinants of Health Research Center (SDHRC), School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran )

Soheila Pirdadeh Beiranvand (Department of Reproductive Health, School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran)

Mahshid Bokaie (Research Center for Nursing and Midwifery Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran )


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks


Abstract | Full Text

Premenstrual syndrome (PMS) encompasses a vast array of physical and psychological symptoms. Of the herbal supplements mentioned for remedy PMS symptoms, chamomile used as an effective herbal medicine. The overall purpose of this review was to determine the efficacy of chamomile on the treatment PMS. An extensive research review using Web of Science, the Cochrane Controlled Trials Register database, PubMed, Chinese Biomedical Database (CBM), CINAHL, China National Knowledge Infrastructure (CNKI), Psych INFO, Social Science Research Network, SID, Google Scholar, Iran Doc, Magiran and Iran Medex. Eligible studies were identified from English and Persian databases, published between 1990 and 2019. Studies were screened independently by two researchers who performed the data extraction. Of Twenty-seven studies identified, Eight RCTs met our inclusion criteria. Chamomile has been used to treat PMS relief because of therapeutic properties such as anti-inflammatory effects (Chamazulene and α-Bisabolol); anti-spasmodic effects (Apigenin, Quercetin, and Luteolin, Metoxicomarin, Matrisin, and Phytoestrogens); anti-anxiety effects (Glycine, Flavonoid). The results of this review show that Chamomile is effective for the treatment of PMS. Based on these results, we believe that Chamomile can be used as good herbal medicine to treat in women with PMS.