Frontiers in Pharmacology (Jun 2020)
CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord
- Gang Zheng,
- Gang Zheng,
- Fanghong Zheng,
- Fanghong Zheng,
- Fanghong Zheng,
- Zucheng Luo,
- Zucheng Luo,
- Haiwei Ma,
- Haiwei Ma,
- Dongdong Zheng,
- Guangheng Xiang,
- Guangheng Xiang,
- Cong Xu,
- Cong Xu,
- Yifei Zhou,
- Yifei Zhou,
- Yifei Zhou,
- Yaosen Wu,
- Yaosen Wu,
- Yaosen Wu,
- Naifeng Tian,
- Naifeng Tian,
- Naifeng Tian,
- Yan Wu,
- Tan Zhang,
- Wenfei Ni,
- Wenfei Ni,
- Sheng Wang,
- Sheng Wang,
- Sheng Wang,
- Huazi Xu,
- Huazi Xu,
- Huazi Xu,
- Xiaolei Zhang,
- Xiaolei Zhang,
- Xiaolei Zhang,
- Xiaolei Zhang
Affiliations
- Gang Zheng
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Gang Zheng
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Fanghong Zheng
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Fanghong Zheng
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Fanghong Zheng
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Zucheng Luo
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Zucheng Luo
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Haiwei Ma
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Haiwei Ma
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Dongdong Zheng
- Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Guangheng Xiang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Guangheng Xiang
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Cong Xu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Cong Xu
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Yifei Zhou
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Yifei Zhou
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Yifei Zhou
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Yaosen Wu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Yaosen Wu
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Yaosen Wu
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Naifeng Tian
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Naifeng Tian
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Naifeng Tian
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Yan Wu
- Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Wenzhou, China
- Tan Zhang
- Department of Orthopaedics, Shaoxing People's Hospital, Shaoxing, Wenzhou, China
- Wenfei Ni
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Wenfei Ni
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Sheng Wang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Sheng Wang
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Sheng Wang
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Huazi Xu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Huazi Xu
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Huazi Xu
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Xiaolei Zhang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
- Xiaolei Zhang
- Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China
- Xiaolei Zhang
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Xiaolei Zhang
- Department of Orthopaedics, Chinese Orthopaedic Regenerative Medicine Society, Hangzhou, China
- DOI
- https://doi.org/10.3389/fphar.2020.00761
- Journal volume & issue
-
Vol. 11
Abstract
Spinal cord injury (SCI) is a clinical tough neurological problem without efficient cure currently. Blood-spinal cord barrier (BSCB) interruption is not only a crucial pathological feature for SCI process but is a possible target for future SCI treatments; however, few treatments have been developed to intervene BSCB. In the present study, we intravenously injected CO-releasing molecule3 (CORM-3), a classical exogenous CO donor, to the rats experiencing SCI and assessed its protection on BSCB integrity in rats. Our results demonstrated that the exogenous increasing of CO by CORM-3 blocked the tight junction (TJ) protein degeneration and neutrophils infiltration, subsequently suppressed the BSCB damage and improved the motor recovery after SCI. And we certified that the CO-induced down-regulation of MMP-9 expression and activity in neutrophil might be associated with the NF-κB signaling. Taken together, our study indicates that CO-releasing molecule (CORM)-3 ameliorates BSCB after spinal cord injury.
Keywords
