Nature Communications (Sep 2022)
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis
- Masanori Fujimoto,
- Masataka Yokoyama,
- Masahiro Kiuchi,
- Hiroyuki Hosokawa,
- Akitoshi Nakayama,
- Naoko Hashimoto,
- Ikki Sakuma,
- Hidekazu Nagano,
- Kazuyuki Yamagata,
- Fujimi Kudo,
- Ichiro Manabe,
- Eunyoung Lee,
- Ryo Hatano,
- Atsushi Onodera,
- Kiyoshi Hirahara,
- Koutaro Yokote,
- Takashi Miki,
- Toshinori Nakayama,
- Tomoaki Tanaka
Affiliations
- Masanori Fujimoto
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Masataka Yokoyama
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Masahiro Kiuchi
- Department of Immunology, Graduate School of Medicine, Chiba University
- Hiroyuki Hosokawa
- Department of Immunology, Tokai University School of Medicine
- Akitoshi Nakayama
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Naoko Hashimoto
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Ikki Sakuma
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Hidekazu Nagano
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Kazuyuki Yamagata
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- Fujimi Kudo
- Department of Systems Medicine, Graduate School of Medicine, Chiba University
- Ichiro Manabe
- Department of Systems Medicine, Graduate School of Medicine, Chiba University
- Eunyoung Lee
- Department of Medical Physiology, Chiba University, Graduate School of Medicine
- Ryo Hatano
- Department of Medical Physiology, Chiba University, Graduate School of Medicine
- Atsushi Onodera
- Department of Immunology, Graduate School of Medicine, Chiba University
- Kiyoshi Hirahara
- Department of Immunology, Graduate School of Medicine, Chiba University
- Koutaro Yokote
- Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University
- Takashi Miki
- Department of Medical Physiology, Chiba University, Graduate School of Medicine
- Toshinori Nakayama
- Department of Immunology, Graduate School of Medicine, Chiba University
- Tomoaki Tanaka
- Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
- DOI
- https://doi.org/10.1038/s41467-022-33171-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Besides hepatocytes, resident immune cells of the liver are also contributing to the body’s energy homeostasis. Here authors show that group 2 innate lymphoid cells interact with a specific set of hepatocytes in suppressing gluconeogenesis and regulate blood glucose levels via Interleukin-13 signalling.
