Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis

Hanyao Huang; Weiyi Pan; Yifan Wang; Hye Sung Kim; Dan Shao; Baoding Huang; Tzu-Chieh Ho; Yeh-Hsing Lao; Chai Hoon Quek; Jiayu Shi; Qianming Chen; Bing Shi; Shengmin Zhang; Lei Zhao; Kam W. Leong

doi:10.1038/s41467-022-33492-6

Nature Communications (Oct 2022)

Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis

Hanyao Huang,
Weiyi Pan,
Yifan Wang,
Hye Sung Kim,
Dan Shao,
Baoding Huang,
Tzu-Chieh Ho,
Yeh-Hsing Lao,
Chai Hoon Quek,
Jiayu Shi,
Qianming Chen,
Bing Shi,
Shengmin Zhang,
Lei Zhao,
Kam W. Leong

Affiliations

Hanyao Huang: State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Weiyi Pan: State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Yifan Wang: Advanced Biomaterials and Tissue Engineering Center and Department of Biomedical Engineering, Huazhong University of Science and Technology
Hye Sung Kim: Department of Biomedical Engineering, Columbia University
Dan Shao: Department of Biomedical Engineering, Columbia University
Baoding Huang: Department of Biomedical Engineering, Columbia University
Tzu-Chieh Ho: Department of Biomedical Engineering, Columbia University
Yeh-Hsing Lao: Department of Biomedical Engineering, Columbia University
Chai Hoon Quek: Department of Biomedical Engineering, Columbia University
Jiayu Shi: Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan
Qianming Chen: State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Bing Shi: State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Shengmin Zhang: Advanced Biomaterials and Tissue Engineering Center and Department of Biomedical Engineering, Huazhong University of Science and Technology
Lei Zhao: State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Kam W. Leong: Department of Biomedical Engineering, Columbia University

DOI: https://doi.org/10.1038/s41467-022-33492-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Periodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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