Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety

Abstract

A series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphosphonate products in moderate to good yields. Studies into their activity as butyrylcholinesterase inhibitors are underway.

Keywords

• phosphonates
• triazole
• copper nanoparticles