Journal of Applied Sciences and Environmental Management (Nov 2023)

Evaluation of Serum Anticardiolipin Antibodies and D-dimer in Recipients of COVID-19 Vaccines in Ado-Ekiti, Ekiti State, Nigeria

  • O. O. Odewusi,
  • J. J. Dodo,
  • F. E. Omotayo,
  • S. O. Obadire,
  • E. A. Omon,
  • M. O. Oguntuase,
  • O. A. Alake

DOI
https://doi.org/10.4314/jasem.v27i11.19
Journal volume & issue
Vol. 27, no. 11

Abstract

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Coronavirus disease 2019 (COVID-19) manifests itself in a variety of ways, implying a wide range of host autoimmune responses which could lead to disseminated intravascular coagulation. This study was designed to evaluate serum anticardiolipin antibodies and D-dimer in recipients of COVID 19 vaccines in Ado-Ekiti, Ekiti State, Nigeria. The study population comprised sixteen (16) fully vaccinated subjects, fifteen (15) partially vaccinated subjects and fifteen (15) unvaccinated subjects (control). Anticardiolipin antibodies and D-dimer were analyzed using ELISA. D-dimer and anticardiolipin antibodies were significantly higher in fully and partially vaccinated subjects compared to control (p0.05). Anticardiolipin and D-dimer were significantly higher in recipients of mRNA vaccines compared to viral vector vaccines (p<0.05). This study discovered that recipients of the COVID-19 immunization have a higher risk of developing antiphospholipid syndrome due to increased anticardiolipin. If disseminated intravascular coagulations is present and its complications are not adequately handled, this could become more serious

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