Nature Communications (Sep 2022)
Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection
- Elham Khatamzas,
- Markus H. Antwerpen,
- Alexandra Rehn,
- Alexander Graf,
- Johannes Christian Hellmuth,
- Alexandra Hollaus,
- Anne-Wiebe Mohr,
- Erik Gaitzsch,
- Tobias Weiglein,
- Enrico Georgi,
- Clemens Scherer,
- Stephanie-Susanne Stecher,
- Stefanie Gruetzner,
- Helmut Blum,
- Stefan Krebs,
- Anna Reischer,
- Alexandra Leutbecher,
- Marion Subklewe,
- Andrea Dick,
- Sabine Zange,
- Philipp Girl,
- Katharina Müller,
- Oliver Weigert,
- Karl-Peter Hopfner,
- Hans-Joachim Stemmler,
- Michael von Bergwelt-Baildon,
- Oliver T. Keppler,
- Roman Wölfel,
- Maximilian Muenchhoff,
- Andreas Moosmann
Affiliations
- Elham Khatamzas
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Markus H. Antwerpen
- Bundeswehr, Institute of Microbiology Munich
- Alexandra Rehn
- Bundeswehr, Institute of Microbiology Munich
- Alexander Graf
- Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians University Munich
- Johannes Christian Hellmuth
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Alexandra Hollaus
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Anne-Wiebe Mohr
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Erik Gaitzsch
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Tobias Weiglein
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Enrico Georgi
- Bundeswehr, Institute of Microbiology Munich
- Clemens Scherer
- COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich
- Stephanie-Susanne Stecher
- Department of Medicine II, University Hospital, Ludwig-Maximilians University Munich
- Stefanie Gruetzner
- Institute for Transfusion Medicine and Haemostasis, Medical Faculty, University of Augsburg
- Helmut Blum
- Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians University Munich
- Stefan Krebs
- Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians University Munich
- Anna Reischer
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Alexandra Leutbecher
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Marion Subklewe
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Andrea Dick
- Laboratory for Immunogenetics, University of Munich, LMU
- Sabine Zange
- Bundeswehr, Institute of Microbiology Munich
- Philipp Girl
- Bundeswehr, Institute of Microbiology Munich
- Katharina Müller
- Bundeswehr, Institute of Microbiology Munich
- Oliver Weigert
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Karl-Peter Hopfner
- Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
- Hans-Joachim Stemmler
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Michael von Bergwelt-Baildon
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- Oliver T. Keppler
- COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich
- Roman Wölfel
- Bundeswehr, Institute of Microbiology Munich
- Maximilian Muenchhoff
- COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich
- Andreas Moosmann
- Department of Medicine III, University Hospital, Ludwig-Maximilians University Munich
- DOI
- https://doi.org/10.1038/s41467-022-32772-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
SARS-CoV-2 mutations associated with the escape from antibody-mediated neutralization have been widely reported. Here, in a patient with defective antibody responses, the authors find a potential association between SARS-CoV-2 mutations and CD8 T alterations to implicate possible contributions of CD8 T cells in evasion of SARS-CoV-2 from host immunity.
