Evaluation of long acting, oral and combination antipsychotic treatments in patients with psychotic disorder (tur)

Abstract

INTRODUCTION[|]The aim of this study was to evaluate the clinical progress, the drug side effects and the relationship between clinical variables and the clinical progress of patients with psychotic disorder who use oral antipsychotic (OA), long-acting antipsychotic (LAA) and combination of two forms (OA+LAA). [¤]METHODS[|]The variables of 250 patients with schizophrenia and other psychotic disorders were analyzed retrospectively from the patient database. The Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), Global Assessment of Functioning (GAF) measurements, clinical variables related to the disease and adverse effects were recorded in the database. The analysis was performed between three groups according to antipsychotic use as OA, LAA (2-4 weeks), OA+LAA with parametric and non-parametric statistical methods. [¤]RESULTS[|]In OA+LAA users, BPRS scores were higher than those using OA or LAA. In OA users, the SAPS and SANS scores were lower and GAF scores were higher than those using OA+LAA. In 4-week LAA users, BPRS scores were higher than those using OA and 2-week LAA. Those with OA had lower SANS, SAPS scores than those with 4-week LAA, and GAF scores were higher than those using LAA for 2 weeks and 4 weeks. [¤]DISCUSSION AND CONCLUSION[|] In our study, it was found that combination therapy with LAA was more preferred in clinically severe cases. The use of LAA may lead to the use of multiple and high-dose drugs, unlike the intended use. Evidence-based data are needed in treatment algorithms in cases with low treatment response, including the use of long-acting forms. [¤]

Keywords

• schizophrenia
• antipsychotics
• side effects