Nature Communications (Jan 2017)

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

  • Zhibing Tan,
  • Yu Liu,
  • Wang Xi,
  • Hui-fang Lou,
  • Liya Zhu,
  • Zhifei Guo,
  • Lin Mei,
  • Shumin Duan

DOI
https://doi.org/10.1038/ncomms13772
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.