Nature Communications (Jan 2017)
Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
Abstract
Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.