Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

Zhibing Tan; Yu Liu; Wang Xi; Hui-fang Lou; Liya Zhu; Zhifei Guo; Lin Mei; Shumin Duan

doi:10.1038/ncomms13772

Nature Communications (Jan 2017)

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

Zhibing Tan,
Yu Liu,
Wang Xi,
Hui-fang Lou,
Liya Zhu,
Zhifei Guo,
Lin Mei,
Shumin Duan

Affiliations

Zhibing Tan: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Yu Liu: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Wang Xi: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Hui-fang Lou: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Liya Zhu: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Zhifei Guo: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine
Lin Mei: Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University
Shumin Duan: Department of Neurobiology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/ncomms13772
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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