Nature Communications (May 2022)
A genetic engineering strategy for editing near-infrared-II fluorophores
- Rui Tian,
- Xin Feng,
- Long Wei,
- Daoguo Dai,
- Ying Ma,
- Haifeng Pan,
- Shengxiang Ge,
- Lang Bai,
- Chaomin Ke,
- Yanlin Liu,
- Lixin Lang,
- Shoujun Zhu,
- Haitao Sun,
- Yanbao Yu,
- Xiaoyuan Chen
Affiliations
- Rui Tian
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Xin Feng
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Long Wei
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Daoguo Dai
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Ying Ma
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Haifeng Pan
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Shengxiang Ge
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Lang Bai
- State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry
- Chaomin Ke
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Yanlin Liu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University
- Lixin Lang
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Shoujun Zhu
- State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry
- Haitao Sun
- State Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University
- Yanbao Yu
- J. Craig Venter Institute, 9714 Medical Center Drive
- Xiaoyuan Chen
- Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-022-30304-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
It is currently difficult to synthesise NIR-II probes with good quantum yields, biocompatibility and pharmacokinetics. Here the authors report a strategy to alter these properties by modifying the protein coatings with biofunctional molecules, and generate long-wavelength fluorophores for in vivo imaging.
