Effect of water temperature and microcystins on the pharmacokinetics of epigallocatechin gallate (EGCG) in snakehead fish (Ophiocephalus argus Cantor)

Abstract

The study was conducted to evaluate the effect of water temperatures and intraperitoneal administration of microcystins (MCs) on the pharmacokinetics characteristics of epigallocatechin gallate (EGCG) in snakehead fish (Ophiocephalus argus Cantor) by RP-HPLC method. The results showed that EGCG was absorbed and eliminated more faster at 20ºC than at 10ºC. Then the detected results also showed that EGCG was significantly absorbed fast in MCs-treated group than in control group. However, EGCG elimination became very lowly in MCs-treated group. Therefore, the pharmacokinetic characteristics of EGCG were significantly affected by water temperature and MCs toxin.