Nature Communications (Nov 2021)
Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights
- Olusegun Isaac Alatise,
- Gregory C. Knapp,
- Avinash Sharma,
- Walid K. Chatila,
- Olukayode A. Arowolo,
- Olalekan Olasehinde,
- Olusola C. Famurewa,
- Adeleye D. Omisore,
- Akinwumi O. Komolafe,
- Olaejinrinde O. Olaofe,
- Aba I. Katung,
- David E. Ibikunle,
- Adedeji A. Egberongbe,
- Samuel A. Olatoke,
- Sulaiman O. Agodirin,
- Olusola A. Adesiyun,
- Ademola Adeyeye,
- Oladapo A. Kolawole,
- Akinwumi O. Olakanmi,
- Kanika Arora,
- Jeremy Constable,
- Ronak Shah,
- Azfar Basunia,
- Brooke Sylvester,
- Chao Wu,
- Martin R. Weiser,
- Ken Seier,
- Mithat Gonen,
- Zsofia K. Stadler,
- Yelena Kemel,
- Efsevia Vakiani,
- Michael F. Berger,
- Timothy A. Chan,
- David B. Solit,
- Jinru Shia,
- Francisco Sanchez-Vega,
- Nikolaus Schultz,
- Murray Brennan,
- J. Joshua Smith,
- T. Peter Kingham
Affiliations
- Olusegun Isaac Alatise
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Gregory C. Knapp
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Avinash Sharma
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Walid K. Chatila
- Marie-Jose and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Olukayode A. Arowolo
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Olalekan Olasehinde
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Olusola C. Famurewa
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Adeleye D. Omisore
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Akinwumi O. Komolafe
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Olaejinrinde O. Olaofe
- Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University
- Aba I. Katung
- Federal Medical Centre
- David E. Ibikunle
- Federal Medical Centre
- Adedeji A. Egberongbe
- Federal Medical Centre
- Samuel A. Olatoke
- Department of Surgery, University of Ilorin Teaching Hospital
- Sulaiman O. Agodirin
- Department of Surgery, University of Ilorin Teaching Hospital
- Olusola A. Adesiyun
- Department of Surgery, University of Ilorin Teaching Hospital
- Ademola Adeyeye
- Department of Surgery, University of Ilorin Teaching Hospital
- Oladapo A. Kolawole
- Department of Surgery, Ladoke Akintola University of Technology
- Akinwumi O. Olakanmi
- Department of Surgery, University of Medical Sciences
- Kanika Arora
- Marie-Jose and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Jeremy Constable
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Ronak Shah
- Marie-Jose and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Azfar Basunia
- Marie-Jose and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Brooke Sylvester
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Chao Wu
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Martin R. Weiser
- Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Ken Seier
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Mithat Gonen
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Zsofia K. Stadler
- Clinical Genetics Service and the Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
- Yelena Kemel
- Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center
- Efsevia Vakiani
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Timothy A. Chan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Jinru Shia
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Francisco Sanchez-Vega
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Nikolaus Schultz
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Murray Brennan
- Bobst International Center, Memorial Sloan Kettering Cancer Center
- J. Joshua Smith
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- T. Peter Kingham
- Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-27106-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is important for early detection and treatment. Here, the authors use a multigene next-generation sequencing panel to identify genomic differences in Nigerian CRCs compared to those from TCGA and MSKCC cohorts.
