Nature Communications (Jan 2022)
Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens
Abstract
N6-methyladenosine (m6A) plays important role in lineage specifications of embryonic stem cells, but its role at specific sites has not been assessed. Here the authors develop an adenine editor-based strategy, and systematically identify functional m6A sites that control lineage decisions in human embryonic stem cells.