Nature Communications (Aug 2018)

A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons

  • Baptiste N. Jaeger,
  • Sara B. Linker,
  • Sarah L. Parylak,
  • Jerika J. Barron,
  • Iryna S. Gallina,
  • Christian D. Saavedra,
  • Conor Fitzpatrick,
  • Christina K. Lim,
  • Simon T. Schafer,
  • Benjamin Lacar,
  • Sebastian Jessberger,
  • Fred H. Gage

DOI
https://doi.org/10.1038/s41467-018-05418-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Single nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by its transcriptional signature.