Frontiers in Medicine (Feb 2022)
Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease
- Shuo-Ming Ou,
- Shuo-Ming Ou,
- Shuo-Ming Ou,
- Shuo-Ming Ou,
- Shuo-Ming Ou,
- Shuo-Ming Ou,
- Kuo-Hua Lee,
- Kuo-Hua Lee,
- Kuo-Hua Lee,
- Kuo-Hua Lee,
- Kuo-Hua Lee,
- Kuo-Hua Lee,
- Ming-Tsun Tsai,
- Ming-Tsun Tsai,
- Ming-Tsun Tsai,
- Ming-Tsun Tsai,
- Ming-Tsun Tsai,
- Ming-Tsun Tsai,
- Wei-Cheng Tseng,
- Wei-Cheng Tseng,
- Wei-Cheng Tseng,
- Wei-Cheng Tseng,
- Wei-Cheng Tseng,
- Wei-Cheng Tseng,
- Yuan-Chia Chu,
- Yuan-Chia Chu,
- Yuan-Chia Chu,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng,
- Der-Cherng Tarng
Affiliations
- Shuo-Ming Ou
- Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Shuo-Ming Ou
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Shuo-Ming Ou
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Shuo-Ming Ou
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
- Shuo-Ming Ou
- Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Shuo-Ming Ou
- Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Kuo-Hua Lee
- Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Kuo-Hua Lee
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Kuo-Hua Lee
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Kuo-Hua Lee
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
- Kuo-Hua Lee
- Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Kuo-Hua Lee
- Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Ming-Tsun Tsai
- Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Ming-Tsun Tsai
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Ming-Tsun Tsai
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Ming-Tsun Tsai
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
- Ming-Tsun Tsai
- Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Ming-Tsun Tsai
- Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Wei-Cheng Tseng
- Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Wei-Cheng Tseng
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Wei-Cheng Tseng
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Wei-Cheng Tseng
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
- Wei-Cheng Tseng
- Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Wei-Cheng Tseng
- Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Yuan-Chia Chu
- Information Management Office, Taipei Veterans General Hospital, Taipei City, Taiwan
- Yuan-Chia Chu
- Big Data Center, Taipei Veterans General Hospital, Taipei City, Taiwan
- Yuan-Chia Chu
- Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
- Der-Cherng Tarng
- Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Der-Cherng Tarng
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Der-Cherng Tarng
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Der-Cherng Tarng
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
- Der-Cherng Tarng
- Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Der-Cherng Tarng
- Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Der-Cherng Tarng
- 0Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan
- Der-Cherng Tarng
- 1Department and Institute of Physiology, National Yang Ming Chiao Tung University, Taipei, Taiwan
- DOI
- https://doi.org/10.3389/fmed.2022.809292
- Journal volume & issue
-
Vol. 9
Abstract
BackgroundSepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown.MethodsFrom 2011 to 2018, we included 1,12,628 patients with chronic kidney disease (CKD) aged ≥ 20 years. The patients with CKD were further divided into 11,661 sepsis group and 1,00,967 non-sepsis group. The following outcome of interest was included: all-cause mortality, readmission for acute kidney injury, estimated glomerular filtration rate decline ≥50% or doubling of serum creatinine, and end-stage renal disease.ResultsAfter propensity score matching, the sepsis group was at higher risks of all-cause mortality [hazard ratio (HR) 1.39, 95% CI, 1.31–1.47], readmission for acute kidney injury (HR 1.67, 95% CI 1.58–1.76), eGFR decline ≥ 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78–4.01), and end-stage renal disease (HR 1.43, 95% CI 1.34–1.53) than non-sepsis group.ConclusionsOur study found that patients with CKD discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events.
Keywords
- sepsis
- chronic kidney disease
- AKI (acute kidney injury)
- renal function decline
- end-stage renal disease
