A Stauffer's syndrome variant associated with renal cell carcinoma and thrombocytopenia

Abstract

Stauffer's syndrome is a rare paraneoplastic manifestation of renal cell carcinoma which is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, α-2-globulin, γ-glutamyl transferase, thrombocytosis, prolongation of prothrombin time and hepatosplenomegaly, in the absence of hepatic metastasis and jaundice. In this case report, we report a patient who was admitted with fever, fatigue, abdominal pain, weight loss and pruritus in whom renal cell carcinoma was incidentally found in the right kidney during an initial workup.

Keywords

• Cholestasis
• Paraneoplastic syndrome
• RCC
• Stauffer's syndrome
• Thrombocytopenia