Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

C. J. Hess; N. Ameziane; G. J. Schuurhuis; A. Errami; F. Denkers; G. J. L. Kaspers; J. Cloos; H. Joenje; D. Reinhardt; G. J. Ossenkoppele; C. M. Zwaan; Q. Waisfisz

doi:10.3233/CLO-2008-0426

Cellular Oncology (Jan 2008)

Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

C. J. Hess,
N. Ameziane,
G. J. Schuurhuis,
A. Errami,
F. Denkers,
G. J. L. Kaspers,
J. Cloos,
H. Joenje,
D. Reinhardt,
G. J. Ossenkoppele,
C. M. Zwaan,
Q. Waisfisz

Affiliations

C. J. Hess: Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
N. Ameziane: Department of Clinical and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
G. J. Schuurhuis: Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
A. Errami: MRC-Holland BV, Amsterdam, The Netherlands
F. Denkers: Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
G. J. L. Kaspers: Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, The Netherlands
J. Cloos: Pediatric Hematology/Oncology, VU University Medical Center, Amsterdam, The Netherlands
H. Joenje: Department of Clinical and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
D. Reinhardt: AML-BFM Study Group, Hannover, Germany
G. J. Ossenkoppele: Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
C. M. Zwaan: Dutch Childhood Oncology Group, Den Haag, The Netherlands
Q. Waisfisz: Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands

DOI: https://doi.org/10.3233/CLO-2008-0426
Journal volume & issue: Vol. 30, no. 4
pp. 299 – 306

Abstract

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Objective: Inactivation of the FA-BRCA pathway results in chromosomal instability. Fanconi anaemia (FA) patients have an inherited defect in this pathway and are strongly predisposed to the development of acute myeloid leukaemia (AML). Studies in sporadic cancers have shown promoter methylation of the FANCF gene in a significant proportion of various solid tumours. However, only a single leukaemic case with methylation of one of the FA-BRCA genes has been described to date, i.e. methylation of FANCF in cell line CHRF-288. We investigated the presence of aberrant methylation in 11 FA-BRCA genes in sporadic cases of leukaemia.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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