Communications Biology (Feb 2023)
Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy
- Kenji Watari,
- Suguru Yamasaki,
- Hung-Ya Tu,
- Masayuki Shikamura,
- Tatsuya Kamei,
- Hideki Adachi,
- Tomoaki Tochitani,
- Yasuyuki Kita,
- Aya Nakamura,
- Kazuki Ueyama,
- Keiichi Ono,
- Chikako Morinaga,
- Take Matsuyama,
- Junki Sho,
- Miyuki Nakamura,
- Masayo Fujiwara,
- Yoriko Hori,
- Anna Tanabe,
- Rina Hirai,
- Orie Terai,
- Osamu Ohno,
- Hidetaka Ohara,
- Tetsuya Hayama,
- Atsushi Ikeda,
- Daiki Nukaya,
- Keizo Matsushita,
- Masayo Takahashi,
- Akiyoshi Kishino,
- Toru Kimura,
- Shin Kawamata,
- Michiko Mandai,
- Atsushi Kuwahara
Affiliations
- Kenji Watari
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Suguru Yamasaki
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Hung-Ya Tu
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Masayuki Shikamura
- Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation at Kobe
- Tatsuya Kamei
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Hideki Adachi
- Preclinical Research Unit, Research Division, Sumitomo Pharma Co., Ltd.
- Tomoaki Tochitani
- Preclinical Research Unit, Research Division, Sumitomo Pharma Co., Ltd.
- Yasuyuki Kita
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Aya Nakamura
- Technology Research & Development Division, Sumitomo Pharma Co., Ltd.
- Kazuki Ueyama
- Technology Research & Development Division, Sumitomo Pharma Co., Ltd.
- Keiichi Ono
- Technology Research & Development Division, Sumitomo Pharma Co., Ltd.
- Chikako Morinaga
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Take Matsuyama
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Junki Sho
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Miyuki Nakamura
- Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation at Kobe
- Masayo Fujiwara
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Yoriko Hori
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Anna Tanabe
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Rina Hirai
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Orie Terai
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Osamu Ohno
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Hidetaka Ohara
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Tetsuya Hayama
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Atsushi Ikeda
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Daiki Nukaya
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Keizo Matsushita
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Masayo Takahashi
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Akiyoshi Kishino
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Toru Kimura
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- Shin Kawamata
- Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation at Kobe
- Michiko Mandai
- Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research
- Atsushi Kuwahara
- Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.
- DOI
- https://doi.org/10.1038/s42003-023-04543-5
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 17
Abstract
Toward tissue/organoid transplantation therapy, a quality control method for human iPSC-derived retinal sheet is presented, and its therapeutic potential is demonstrated in preclinical safety and efficacy studies.
