Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Zhengzheng Yan; Haihua Luo; Bingyao Xie; Tian Tian; Shan Li; Zhixia Chen; Jinghua Liu; Xuwen Zhao; Liyong Zhang; Yongqiang Deng; Timothy R. Billiar; Yong Jiang

doi:10.1038/s41467-020-20577-3

Nature Communications (Jan 2021)

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Zhengzheng Yan,
Haihua Luo,
Bingyao Xie,
Tian Tian,
Shan Li,
Zhixia Chen,
Jinghua Liu,
Xuwen Zhao,
Liyong Zhang,
Yongqiang Deng,
Timothy R. Billiar,
Yong Jiang

Affiliations

Zhengzheng Yan: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Haihua Luo: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Bingyao Xie: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Tian Tian: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Shan Li: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Zhixia Chen: Department of Surgery, University of Pittsburgh School of Medicine
Jinghua Liu: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Xuwen Zhao: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Liyong Zhang: Department of Surgery, University of Pittsburgh School of Medicine
Yongqiang Deng: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University
Timothy R. Billiar: Department of Surgery, University of Pittsburgh School of Medicine
Yong Jiang: Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University

DOI: https://doi.org/10.1038/s41467-020-20577-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

RAGE signalling is implicated in sepsis. Here the authors use T7 phage display to identify SLP76 as a binding partner for the cytosolic tail of RAGE and provide a reagent that can block this interaction and protect mice from sepsis in a caecal ligation and puncture model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal