Relationship Between Gestational Diabetes and Thyroid Hormones in Pregnant Women

Abstract

Objective:Gestational diabetes and thyroid disorders are common disorders during pregnancy. This study investigated the relationship between gestational diabetes and thyroid hormone levels in pregnant women.Method:This single-center study was conducted by analyzing retrospectively 190 pregnant women who admitted to the private internal medicine clinic between March 2019 and December 2022. Ninety pregnant women diagnosed with gestational diabetes mellitus (GDM) and one hundred pregnant women without GDM diagnosis were included in the study. The relationship between thyroid markers [thyroid-stimulating hormone (TSH) and free thyroxine hormone 4 (fT4)] and gestational diabetes was examined.Results:Results did not show a statistically significant association between case and control regarding age and body mass index (p-value >0.05). There was a statistically significant difference between groups regarding TSH (p-value 0.05). There was a statistically meaningful association between healthy women and women with GDM in terms of subclinical hypothyroidism frequency (p-value <0.05).Conclusion:TSH levels, fasting blood glucose and hypothyroidism are among the risk factors for the development of the gestational diabetes.

Keywords

• diabetes
• hypothyroidism
• gestational diabetes mellitus
• pregnancy
• thyroid disorders