Frontiers in Public Health (Mar 2023)
Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study
- Tao Yu,
- Tao Yu,
- Tao Yu,
- Tao Yu,
- Tao Yu,
- Hanna Wu,
- Hanna Wu,
- Hanna Wu,
- Hanna Wu,
- Hanna Wu,
- Qingxia Huang,
- Fen Dong,
- Fen Dong,
- Fen Dong,
- Fen Dong,
- Xuexin Li,
- Xuexin Li,
- Xuexin Li,
- Xuexin Li,
- Xuexin Li,
- Yushi Zhang,
- Yushi Zhang,
- Yushi Zhang,
- Yushi Zhang,
- Yushi Zhang,
- Ruirui Duan,
- Ruirui Duan,
- Ruirui Duan,
- Ruirui Duan,
- Hongtao Niu,
- Hongtao Niu,
- Hongtao Niu,
- Hongtao Niu,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Ting Yang
Affiliations
- Tao Yu
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Tao Yu
- National Center for Respiratory Medicine, Beijing, China
- Tao Yu
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Tao Yu
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Tao Yu
- Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
- Hanna Wu
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Hanna Wu
- National Center for Respiratory Medicine, Beijing, China
- Hanna Wu
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Hanna Wu
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Hanna Wu
- Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China
- Qingxia Huang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Metabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular Phenomics, Fudan University, Shanghai, China
- Fen Dong
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Fen Dong
- National Center for Respiratory Medicine, Beijing, China
- Fen Dong
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Fen Dong
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xuexin Li
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Xuexin Li
- National Center for Respiratory Medicine, Beijing, China
- Xuexin Li
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Xuexin Li
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xuexin Li
- Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China
- Yushi Zhang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Yushi Zhang
- National Center for Respiratory Medicine, Beijing, China
- Yushi Zhang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Yushi Zhang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Yushi Zhang
- Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
- Ruirui Duan
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Ruirui Duan
- National Center for Respiratory Medicine, Beijing, China
- Ruirui Duan
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Ruirui Duan
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Hongtao Niu
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Hongtao Niu
- National Center for Respiratory Medicine, Beijing, China
- Hongtao Niu
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Hongtao Niu
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Ting Yang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Ting Yang
- National Center for Respiratory Medicine, Beijing, China
- Ting Yang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Ting Yang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- DOI
- https://doi.org/10.3389/fpubh.2023.1069906
- Journal volume & issue
-
Vol. 11
Abstract
IntroductionThe metabolomic changes caused by airborne fine particulate matter (PM2.5) exposure in patients with chronic obstructive pulmonary disease (COPD) remain unclear. The aim of this study was to determine whether it is possible to predict PM2.5-induced acute exacerbation of COPD (AECOPD) using metabolic markers.MethodsThirty-eight patients with COPD diagnosed by the 2018 Global Initiative for Obstructive Lung Disease were selected and divided into high exposure and low exposure groups. Questionnaire data, clinical data, and peripheral blood data were collected from the patients. Targeted metabolomics using liquid chromatography-tandem mass spectrometry was performed on the plasma samples to investigate the metabolic differences between the two groups and its correlation with the risk of acute exacerbation.ResultsMetabolomic analysis identified 311 metabolites in the plasma of patients with COPD, among which 21 metabolites showed significant changes between the two groups, involving seven pathways, including glycerophospholipid, alanine, aspartate, and glutamate metabolism. Among the 21 metabolites, arginine and glycochenodeoxycholic acid were positively associated with AECOPD during the three months of follow-up, with an area under the curve of 72.50% and 67.14%, respectively.DiscussionPM2.5 exposure can lead to changes in multiple metabolic pathways that contribute to the development of AECOPD, and arginine is a bridge between PM2.5 exposure and AECOPD.
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