Nature Communications (Jun 2021)

Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

  • Nikolaos Kaplaneris,
  • Jongwoo Son,
  • Lorena Mendive-Tapia,
  • Adelina Kopp,
  • Nicole D. Barth,
  • Isaac Maksso,
  • Marc Vendrell,
  • Lutz Ackermann

DOI
https://doi.org/10.1038/s41467-021-23462-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.