Orthobunyaviruses: From Virus Binding to Penetration into Mammalian Host Cells
Stefan Windhaber,
Qilin Xin,
Pierre-Yves Lozach
Affiliations
Stefan Windhaber
CellNetworks—Cluster of Excellence and Center for Integrative Infectious Diseases Research (CIID), Department of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany
Qilin Xin
Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Pratique des Hautes Etudes (EPHE), Viral Infections and Comparative Pathology (IVPC), UMR754-University Lyon, 69007 Lyon, France
Pierre-Yves Lozach
CellNetworks—Cluster of Excellence and Center for Integrative Infectious Diseases Research (CIID), Department of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany
With over 80 members worldwide, Orthobunyavirus is the largest genus in the Peribunyaviridae family. Orthobunyaviruses (OBVs) are arthropod-borne viruses that are structurally simple, with a trisegmented, negative-sense RNA genome and only four structural proteins. OBVs are potential agents of emerging and re-emerging diseases and overall represent a global threat to both public and veterinary health. The focus of this review is on the very first steps of OBV infection in mammalian hosts, from virus binding to penetration and release of the viral genome into the cytosol. Here, we address the most current knowledge and advances regarding OBV receptors, endocytosis, and fusion.
