Nutrients (Oct 2023)

The Nephroprotective Effect of Cornelian Cherry (<i>Cornus mas</i> L.) and Rowanberry (<i>Sorbus aucuparia</i> L.) in Gentamicin-Induced Nephrotoxicity on Wistar Rats with Emphasis on the Evaluation of Novel Renal Biomarkers and the Antioxidant Capacity in Correlation with Nitro-Oxidative Stress

  • Mara Aurori,
  • Sanda Andrei,
  • Alexandra Iulia Dreanca,
  • Andreea Georgiana Morohoschi,
  • Mihaela Cotul,
  • Mihaela Niculae,
  • Monica Irina Nan,
  • Andrei Răzvan Codea,
  • Adrian Florin Gal

DOI
https://doi.org/10.3390/nu15204392
Journal volume & issue
Vol. 15, no. 20
p. 4392

Abstract

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In spite of its well-known nephrotoxicity, gentamicin is nonetheless routinely used in humans and animals. However, no adjuvant treatments have been implemented to mitigate this harmful effect. Given this concern, medicinal plants represent a significant reservoir of natural antioxidants that could potentially reduce the renal oxidative stress induced by gentamicin. Therefore, the main objective of this research was to investigate the nephroprotective properties of Cornus mas and Sorbus aucuparia fruits in an experimental model of nephrotoxicity. The 3-week study was performed on male Wistar rats, which were randomly divided into six experimental groups, being subcutaneously treated with 50 mg/kg gentamicin and orally given Cornus mas and Sorbus aucuparia extracts, in doses of 40 mg/kg and 10 mg/kg, respectively. Antioxidant therapy significantly improved the nitro-oxidative stress parameters as well as the specific renal biomarkers KIM-1 and iNAG, demonstrating a considerable renal tubular protective impact. These outcomes were reinforced by biochemical and histopathological enhancements. Nevertheless, neither of the tested extracts succeeded in substantially diminishing BUN levels. Additionally, CysC did not significantly decline following extracts treatment, suggesting that the remedies did not effectively protect renal glomeruli against gentamicin stress. Future studies are required in order to determine the underlying mechanisms of these berries.

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