Nature Communications (Apr 2019)
K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
- Qing Yin,
- Tao Han,
- Bin Fang,
- Guolin Zhang,
- Chao Zhang,
- Evan R. Roberts,
- Victoria Izumi,
- Mengmeng Zheng,
- Shulong Jiang,
- Xiu Yin,
- Minjung Kim,
- Jianfeng Cai,
- Eric B. Haura,
- John M. Koomen,
- Keiran S. M. Smalley,
- Lixin Wan
Affiliations
- Qing Yin
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Tao Han
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Bin Fang
- Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute
- Guolin Zhang
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Chao Zhang
- Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute
- Evan R. Roberts
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Victoria Izumi
- Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute
- Mengmeng Zheng
- Department of Chemistry, University of South Florida
- Shulong Jiang
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Xiu Yin
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Minjung Kim
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Jianfeng Cai
- Department of Chemistry, University of South Florida
- Eric B. Haura
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- John M. Koomen
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Keiran S. M. Smalley
- Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute
- Lixin Wan
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-09844-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
BRAF drives MEK/ERK activation to facilitate tumorigenesis. Here, the authors show that in response to pro-inflammatory cytokines, ITCH mediates a non-proteolytic ubiquitination and activation of BRAF, which in turn sustains MEK/ERK signaling to facilitate melanoma cell growth.
