Nature Communications (Jan 2021)
A RAC-GEF network critical for early intestinal tumourigenesis
- K. A. Pickering,
- K. Gilroy,
- J. W. Cassidy,
- S. K. Fey,
- A. K. Najumudeen,
- L. B. Zeiger,
- D. F. Vincent,
- D. M. Gay,
- J. Johansson,
- R. P. Fordham,
- B. Miller,
- W. Clark,
- A. Hedley,
- E. B. Unal,
- C. Kiel,
- E. McGhee,
- L. M. Machesky,
- C. Nixon,
- A. E. Johnsson,
- M. Bain,
- D. Strathdee,
- S. R. van Hoof,
- J. P. Medema,
- K. I. Anderson,
- S. M. Brachmann,
- V. M. Stucke,
- A. Malliri,
- M. Drysdale,
- M. Turner,
- L. Serrano,
- K. Myant,
- A. D. Campbell,
- O. J. Sansom
Affiliations
- K. A. Pickering
- CRUK Beatson Institute, Garscube Estate
- K. Gilroy
- CRUK Beatson Institute, Garscube Estate
- J. W. Cassidy
- CRUK Cambridge Institute, University of Cambridge, Robinson Way
- S. K. Fey
- CRUK Beatson Institute, Garscube Estate
- A. K. Najumudeen
- CRUK Beatson Institute, Garscube Estate
- L. B. Zeiger
- CRUK Beatson Institute, Garscube Estate
- D. F. Vincent
- CRUK Beatson Institute, Garscube Estate
- D. M. Gay
- CRUK Beatson Institute, Garscube Estate
- J. Johansson
- CRUK Beatson Institute, Garscube Estate
- R. P. Fordham
- CRUK Beatson Institute, Garscube Estate
- B. Miller
- CRUK Beatson Institute, Garscube Estate
- W. Clark
- CRUK Beatson Institute, Garscube Estate
- A. Hedley
- CRUK Beatson Institute, Garscube Estate
- E. B. Unal
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC)
- C. Kiel
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC)
- E. McGhee
- CRUK Beatson Institute, Garscube Estate
- L. M. Machesky
- CRUK Beatson Institute, Garscube Estate
- C. Nixon
- CRUK Beatson Institute, Garscube Estate
- A. E. Johnsson
- The Babraham Institute, Babraham Hall, Babraham
- M. Bain
- IBAHCM and School of Veterinary Medicine, 464 Bearsden Road, Bearsden
- D. Strathdee
- CRUK Beatson Institute, Garscube Estate
- S. R. van Hoof
- Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center
- J. P. Medema
- Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center
- K. I. Anderson
- The Francis Crick Institute, Mill Hill Laboratory
- S. M. Brachmann
- Novartis Institutes for BioMedical Research
- V. M. Stucke
- Novartis Institutes for BioMedical Research
- A. Malliri
- CRUK Manchester Institute
- M. Drysdale
- Broad Institute
- M. Turner
- The Babraham Institute, Babraham Hall, Babraham
- L. Serrano
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC)
- K. Myant
- Edinburgh Research Centre, The Institute of Genetics and Molecular Medicine
- A. D. Campbell
- CRUK Beatson Institute, Garscube Estate
- O. J. Sansom
- CRUK Beatson Institute, Garscube Estate
- DOI
- https://doi.org/10.1038/s41467-020-20255-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Loss of small GTPase RAC1 suppresses intestinal tumorigenesis caused by APC loss, but impacts normal intestinal homeostasis. Here, the authors provide an alternative method of reducing RAC1 activity by the combined targeting of three RAC-GEFs and show that this approach delays intestinal tumorigenesis without the detrimental effects on normal intestinal architecture.
