Frontiers in Immunology (Mar 2022)
PgtE Enzyme of Salmonella enterica Shares the Similar Biological Roles to Plasminogen Activator (Pla) in Interacting With DEC-205 (CD205), and Enhancing Host Dissemination and Infectivity by Yersinia pestis
- Qiao Li,
- Chenglin Ye,
- Fei Zhao,
- Wenjin Li,
- Sizhe Zhu,
- Yin Lv,
- Chae Gyu Park,
- Chae Gyu Park,
- Yingmiao Zhang,
- Ling-Yu Jiang,
- Kun Yang,
- Yingxia He,
- Huahua Cai,
- Song Zhang,
- Hong-Hui Ding,
- Olivia Adhiambo Njiri,
- John Mambwe Tembo,
- Ayman Ahmad Alkraiem,
- Ayman Ahmad Alkraiem,
- An-Yi Li,
- Zi-Yong Sun,
- Wei Li,
- Mei-Ying Yan,
- Biao Kan,
- Xixiang Huo,
- John D. Klena,
- Mikael Skurnik,
- Andrey P. Anisimov,
- Xiaofang Gao,
- Yanping Han,
- Rui-Fu Yang,
- Xiding Xiamu,
- Yuanzhi Wang,
- Hongxiang Chen,
- Bao Chai,
- Bao Chai,
- Yicheng Sun,
- Jingping Yuan,
- Tie Chen
Affiliations
- Qiao Li
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Chenglin Ye
- Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China
- Fei Zhao
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Wenjin Li
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Sizhe Zhu
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Yin Lv
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Chae Gyu Park
- Therapeutic Antibody Research Center, Genuv Inc., Seoul, South Korea
- Chae Gyu Park
- Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences, Ewha Womans University, Seoul, South Korea
- Yingmiao Zhang
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Ling-Yu Jiang
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Kun Yang
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Yingxia He
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Huahua Cai
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Song Zhang
- Union Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Hong-Hui Ding
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Olivia Adhiambo Njiri
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- John Mambwe Tembo
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Ayman Ahmad Alkraiem
- Tongji Hospital, Tongji Medical College, Huazhong University, Wuhan, China
- Ayman Ahmad Alkraiem
- Department of Biology, College of Science, Taibah University, Medina, Saudi Arabia
- An-Yi Li
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Zi-Yong Sun
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Wei Li
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Mei-Ying Yan
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Biao Kan
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Xixiang Huo
- Center for Infectious Diseases, Hubei Provincial Centers for Disease Control and Prevention (CDC), Wuhan, China
- John D. Klena
- 0Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States
- Mikael Skurnik
- 1Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
- Andrey P. Anisimov
- 2Laboratory for Plague Microbiology, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia
- Xiaofang Gao
- 3State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Yanping Han
- 3State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Rui-Fu Yang
- 3State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Xiding Xiamu
- 4Division of Disease Control and Prevention for Endemic Diseases , Wenquan Center for Disease Control and Prevention, Wenquan, China
- Yuanzhi Wang
- 5Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, China
- Hongxiang Chen
- Union Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- Bao Chai
- 6Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
- Bao Chai
- 7Department of Dermatology, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
- Yicheng Sun
- 8Ministry of Health (MOH) Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- Jingping Yuan
- Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China
- Tie Chen
- Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
- DOI
- https://doi.org/10.3389/fimmu.2022.791799
- Journal volume & issue
-
Vol. 13
Abstract
Yersinia pestis, the cause of plague, is a newly evolved Gram-negative bacterium. Through the acquisition of the plasminogen activator (Pla), Y. pestis gained the means to rapidly disseminate throughout its mammalian hosts. It was suggested that Y. pestis utilizes Pla to interact with the DEC-205 (CD205) receptor on antigen-presenting cells (APCs) to initiate host dissemination and infection. However, the evolutionary origin of Pla has not been fully elucidated. The PgtE enzyme of Salmonella enterica, involved in host dissemination, shows sequence similarity with the Y. pestis Pla. In this study, we demonstrated that both Escherichia coli K-12 and Y. pestis bacteria expressing the PgtE-protein were able to interact with primary alveolar macrophages and DEC-205-transfected CHO cells. The interaction between PgtE-expressing bacteria and DEC-205-expressing transfectants could be inhibited by the application of an anti-DEC-205 antibody. Moreover, PgtE-expressing Y. pestis partially re-gained the ability to promote host dissemination and infection. In conclusion, the DEC-205-PgtE interaction plays a role in promoting the dissemination and infection of Y. pestis, suggesting that Pla and the PgtE of S. enterica might share a common evolutionary origin.
Keywords
