Analysis of antimicrobial resistance to 7 antimicrobial agents in 587 strains of Neisseria gonorrhoeae

Abstract

Objective: To investigate the antimicrobial resistance to 7 antimicrobial agents of clinical isolates of Neisseria gonorrhoeae in our hospital from 2016 to 2018. Methods: A total of 587 Neisseria gonorrhoeae were isolated during January 2016 to December 2018.Minimal inhibitory concentrations (MIC) of Penicillin, Tetracycline, Ciprofloxacin, Spectinomycin, Cefixime, Ceftriaxone, Azithromycin were determined by the micro broth dilution method, penicillinase-producing Neisseria gonorrhoeae (PPNG) was detected by the paper acidometric testing. The resistance of all strains was interpreted according to criteria used in the project of surveillance of gonococcal antibiotic susceptibility in the WHO Western Pacific Region. Results: Of the 587 Neisseria gonorrhoeae, penicillinase-producing Neisseria gonorrhoeae (PPNG) accounted for 38.5% (226/587), plasmid-mediated Tetracycline-Resistant Neisseria gonorrhoeae (TRNG) accounted for 37.1% (218/587). There were no significant difference about PPNG (χ2=3.51, P>0.05) and TRNG (χ2=3.26, P>0.05) prevalence rate in three years. The prevalence of Penicillin, Ciprofloxacin, Tetracycline and Azithromycin-resistance was accounted for 73.8%, 99.7%, 95.6%, 17.9%, respectively. No Neisseria gonorrhoeae was found resistant to Ceftriaxone, Cefixime and Spectinomycin, but 6.5% (38/587) and 9.9% (58/587) showed reduced sensitivity to Ceftriaxone and Cefixime. Conclusions: A total of 587 Neisseria gonorrhoeae strains are highly resistant to Penicillin, Ciprofloxacin and Tetracycline, while sensitive to Ceftriaxone, Cefixime and Spectinomycin. Continuous surveillance of drug resistance of Neisseria gonorrhoeae is most important and valuable in understanding the trend of antimicrobial resistance and rational antimicrobial therapy.

Keywords

• neisseria gonorrhoeae
• mic
• ppng
• trng
• resistance surveillance