Single-nucleotide conservation state annotation of the SARS-CoV-2 genome

Abstract

Kwon and Ernst applied the comparative genomics method, ConsHMM, to the multi-strain alignments of different coronaviruses in order to annotate every base of the SARS-CoV-2 genome with conservation states. The conservation states reflect sequence alignment patterns among different coronaviruses, which would assist with understanding the functional consequences of SARS-CoV-2 mutations.