Nature Communications (Nov 2017)
Mammalian γ2 AMPK regulates intrinsic heart rate
- Arash Yavari,
- Mohamed Bellahcene,
- Annalisa Bucchi,
- Syevda Sirenko,
- Katalin Pinter,
- Neil Herring,
- Julia J. Jung,
- Kirill V. Tarasov,
- Emily J. Sharpe,
- Markus Wolfien,
- Gabor Czibik,
- Violetta Steeples,
- Sahar Ghaffari,
- Chinh Nguyen,
- Alexander Stockenhuber,
- Joshua R. St. Clair,
- Christian Rimmbach,
- Yosuke Okamoto,
- Dongmei Yang,
- Mingyi Wang,
- Bruce D. Ziman,
- Jack M. Moen,
- Daniel R. Riordon,
- Christopher Ramirez,
- Manuel Paina,
- Joonho Lee,
- Jing Zhang,
- Ismayil Ahmet,
- Michael G. Matt,
- Yelena S. Tarasova,
- Dilair Baban,
- Natasha Sahgal,
- Helen Lockstone,
- Rathi Puliyadi,
- Joseph de Bono,
- Owen M. Siggs,
- John Gomes,
- Hannah Muskett,
- Mahon L. Maguire,
- Youlia Beglov,
- Matthew Kelly,
- Pedro P. N. dos Santos,
- Nicola J. Bright,
- Angela Woods,
- Katja Gehmlich,
- Henrik Isackson,
- Gillian Douglas,
- David J. P. Ferguson,
- Jürgen E. Schneider,
- Andrew Tinker,
- Olaf Wolkenhauer,
- Keith M. Channon,
- Richard J. Cornall,
- Eduardo B. Sternick,
- David J. Paterson,
- Charles S. Redwood,
- David Carling,
- Catherine Proenza,
- Robert David,
- Mirko Baruscotti,
- Dario DiFrancesco,
- Edward G. Lakatta,
- Hugh Watkins,
- Houman Ashrafian
Affiliations
- Arash Yavari
- Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford
- Mohamed Bellahcene
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Annalisa Bucchi
- Department of Biosciences, Università degli Studi di Milano
- Syevda Sirenko
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Katalin Pinter
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Neil Herring
- Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of Oxford
- Julia J. Jung
- Department of Cardiac Surgery, Rostock University Medical Centre
- Kirill V. Tarasov
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Emily J. Sharpe
- Department of Physiology and Biophysics, University of Colorado School of Medicine
- Markus Wolfien
- Department of Systems Biology and Bioinformatics, University of Rostock
- Gabor Czibik
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Violetta Steeples
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Sahar Ghaffari
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Chinh Nguyen
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Alexander Stockenhuber
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Joshua R. St. Clair
- Department of Physiology and Biophysics, University of Colorado School of Medicine
- Christian Rimmbach
- Department of Cardiac Surgery, Rostock University Medical Centre
- Yosuke Okamoto
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Dongmei Yang
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Mingyi Wang
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Bruce D. Ziman
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Jack M. Moen
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Daniel R. Riordon
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Christopher Ramirez
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Manuel Paina
- Department of Biosciences, Università degli Studi di Milano
- Joonho Lee
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Jing Zhang
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Ismayil Ahmet
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Michael G. Matt
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Yelena S. Tarasova
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Dilair Baban
- The Wellcome Trust Centre for Human Genetics
- Natasha Sahgal
- The Wellcome Trust Centre for Human Genetics
- Helen Lockstone
- The Wellcome Trust Centre for Human Genetics
- Rathi Puliyadi
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Joseph de Bono
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Owen M. Siggs
- The Wellcome Trust Centre for Human Genetics
- John Gomes
- Department of Medicine, BHF Laboratories, The Rayne Institute, University College London
- Hannah Muskett
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Mahon L. Maguire
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Youlia Beglov
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Matthew Kelly
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Pedro P. N. dos Santos
- Instituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas Gerais
- Nicola J. Bright
- Cellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London
- Angela Woods
- Cellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London
- Katja Gehmlich
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Henrik Isackson
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Gillian Douglas
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- David J. P. Ferguson
- Nuffield Department of Clinical Laboratory Science, University of Oxford
- Jürgen E. Schneider
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Andrew Tinker
- Department of Medicine, BHF Laboratories, The Rayne Institute, University College London
- Olaf Wolkenhauer
- Department of Systems Biology and Bioinformatics, University of Rostock
- Keith M. Channon
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Richard J. Cornall
- The Wellcome Trust Centre for Human Genetics
- Eduardo B. Sternick
- Instituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas Gerais
- David J. Paterson
- Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of Oxford
- Charles S. Redwood
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- David Carling
- Cellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London
- Catherine Proenza
- Department of Physiology and Biophysics, University of Colorado School of Medicine
- Robert David
- Department of Cardiac Surgery, Rostock University Medical Centre
- Mirko Baruscotti
- Department of Biosciences, Università degli Studi di Milano
- Dario DiFrancesco
- Department of Biosciences, Università degli Studi di Milano
- Edward G. Lakatta
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH
- Hugh Watkins
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Houman Ashrafian
- Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-017-01342-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.
