Frontiers in Medicine (Nov 2021)
Case Report: A Rare Case of Lupus Nephritis Associated With Mantle Cell Lymphoma
- Daorina Bao,
- Daorina Bao,
- Daorina Bao,
- Daorina Bao,
- Daorina Bao,
- Ying Tan,
- Ying Tan,
- Ying Tan,
- Ying Tan,
- Ying Tan,
- Xiaojuan Yu,
- Xiaojuan Yu,
- Xiaojuan Yu,
- Xiaojuan Yu,
- Xiaojuan Yu,
- Bingjie Wang,
- Hui Wang,
- Rong Xu,
- Rong Xu,
- Rong Xu,
- Rong Xu,
- Rong Xu,
- Fude Zhou,
- Fude Zhou,
- Fude Zhou,
- Fude Zhou,
- Fude Zhou,
- Minghui Zhao,
- Minghui Zhao,
- Minghui Zhao,
- Minghui Zhao,
- Minghui Zhao,
- Minghui Zhao
Affiliations
- Daorina Bao
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Daorina Bao
- Institute of Nephrology, Peking University, Beijing, China
- Daorina Bao
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Daorina Bao
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Daorina Bao
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Ying Tan
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Ying Tan
- Institute of Nephrology, Peking University, Beijing, China
- Ying Tan
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Ying Tan
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Ying Tan
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Xiaojuan Yu
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Xiaojuan Yu
- Institute of Nephrology, Peking University, Beijing, China
- Xiaojuan Yu
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Xiaojuan Yu
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Xiaojuan Yu
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Bingjie Wang
- Department of Hematology, Peking University First Hospital, Beijing, China
- Hui Wang
- Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China
- Rong Xu
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Rong Xu
- Institute of Nephrology, Peking University, Beijing, China
- Rong Xu
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Rong Xu
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Rong Xu
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Fude Zhou
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Fude Zhou
- Institute of Nephrology, Peking University, Beijing, China
- Fude Zhou
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Fude Zhou
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Fude Zhou
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Minghui Zhao
- Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
- Minghui Zhao
- Institute of Nephrology, Peking University, Beijing, China
- Minghui Zhao
- Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
- Minghui Zhao
- Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China
- Minghui Zhao
- Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China
- Minghui Zhao
- Peking-Tsinghua Center for Life Sciences, Beijing, China
- DOI
- https://doi.org/10.3389/fmed.2021.759279
- Journal volume & issue
-
Vol. 8
Abstract
In this research, we described a very rare case of secondary lupus nephritis associated with B-cell lymphoma. An 84-year-old man was hospitalized at our institute for lower extremity edema persisting for over 2 months. He was diagnosed with systemic lupus erythematosus based on clinical and laboratory criteria, which showed impaired renal function and nephrotic syndrome with predominant hematuria. Renal biopsy showed IV+V lupus nephritis with highly infiltrated lymphoid cells in the kidney. Secondary lupus nephritis was suspected based on the possible pathogenesis of glomerular injury due to mantle cell lymphoma. Low-dose dexamethasone, rituximab, and lenalidomide were immediately started on the patient, and his renal function was improved after the first cycle of chemotherapy.
Keywords
