Fuel-propelled nanomotors for acute kidney injury applications

Weixin Wang; Rui Gao; Lin Zhang; Zhongchao Wang; Jiahui Sun; Lei Luo; Min Pan; Miaofang Hong; Jianming Wu; Qibing Mei; Ke Tong; Yini Wang; Lingyan Qiao; Fei Tong

Pharmaceutical Science Advances (Dec 2024)

Fuel-propelled nanomotors for acute kidney injury applications

Weixin Wang,
Rui Gao,
Lin Zhang,
Zhongchao Wang,
Jiahui Sun,
Lei Luo,
Min Pan,
Miaofang Hong,
Jianming Wu,
Qibing Mei,
Ke Tong,
Yini Wang,
Lingyan Qiao,
Fei Tong

Affiliations

Weixin Wang: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Rui Gao: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Lin Zhang: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Zhongchao Wang: Institute of Cardiovascular Disease, Shanxi Medical University, Taiyuan, 030001, China
Jiahui Sun: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Lei Luo: Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China
Min Pan: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Miaofang Hong: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Jianming Wu: Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou, China; Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China
Qibing Mei: Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou, China; Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China
Ke Tong: Southwest University of Science and Technology, 621000, Mianyang, China; Corresponding author.
Yini Wang: Clinical Medical College, Binzhou Medical University, Yantai, 264003, China; Corresponding author.
Lingyan Qiao: Clinical Medical College, Binzhou Medical University, Yantai, 264003, China; Corresponding author.
Fei Tong: Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; Corresponding author.

Journal volume & issue: Vol. 2
p. 100044

Abstract

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Acute kidney injury (AKI) is characterized by a rapid loss of renal metabolic function and a high mortality rate. Although significant progress has been made in developing targeted drugs for AKI treatment, issues such as inadequate antioxidant effects and poor renal enrichment efficiency remain. Nanomotors can enhance drug delivery efficiency in AKI treatments through self-propulsion in the microenvironment or via external stimuli. We reviewed recent progress in the targeted treatment of AKI with nanomotors, focusing on their contribution to targeted drug delivery at different stages and combined treatments. Current limitations and future development directions are also discussed.

Published in Pharmaceutical Science Advances

ISSN: 2773-2169 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pharmacy and materia medica; Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/pharmaceutical-science-advances

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