Nature Communications (Sep 2021)

Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

  • Zhen Wang,
  • Lijian Xie,
  • Guohui Ding,
  • Sirui Song,
  • Liqin Chen,
  • Guang Li,
  • Min Xia,
  • Dingding Han,
  • Yue Zheng,
  • Jia Liu,
  • Tingting Xiao,
  • Hong Zhang,
  • Yujuan Huang,
  • Yixue Li,
  • Min Huang

DOI
https://doi.org/10.1038/s41467-021-25771-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.