Nature Communications (Sep 2021)
Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
Abstract
Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.